Green Analytical Chemistry in Pharmaceuticals (GAC)
Analytical instruments used in the field of analytical chemistry include conventional methods like high-pressure liquid chromatography and gas chromatography. These methods use solvents, consume more energy consumption and produce debris, which seriously threaten the natural environment. The overindulgence of more organic solvents, along with the harmful debris produced from them, can pollute the environment. So, New Green Analytical Chemistry pathways are developed by scientists to manage this environmental trouble and make it environmentally safe.
Green analytical chemistry is implemented, and focusing on it in the laboratory is well-liked in the realm of chemicals. In the whole world, chemists and pharmacists are working on GAC to make it viable. Green chemistry can adopt various configurations, such as modifications in practice with more eco-friendly substances or actively handling wastes. Firstly, Paul Anastas termed “green chemistry” as a branch of science that focuses on completely removing or reducing the manufacturing of harmful chemical compounds during chemical processes. The first steps in the expenditure of green analytical chemistry (GAC) in the analytical chemistry branch were taken in 1995 when Paul Anastas emphasized that need to discover Green Analytical Chemistry principles in an article that was publicized in a special article of the Analyst journal that was concerned to the diminishing, satisfaction, and chemical replacement in analytical chemistry.
The effectiveness of green chemistry paths relates to conventional methods; many methods have been devised. Green Analytical Chemistry is based on various Principles. It includes, Energy consumption, which should be smaller, Reduce particle size and amount as much as possible, Use direct analysis practicable, Produce waste should be smaller, and good waste management is necessary, Analysis must to be done on-site wherever possible, use less harmful and safer chemicals, use renewable and maintainable reagents, maintain secure operating environment etc. These principles are extensively useful in pharmaceutical analysis.
Green analytical chemistry is used in the analysis of drug concentrations in blood or urine and is also applied in pharmacokinetic and pharmacodynamic studies. Green analytical methods are also used in quality control laboratories to confirm the quality and safety of drugs. It is also used to find impurities and degradation products in pharmaceutical formulations.
By incorporating GAC approaches, the pharmaceutical industry can contribute to a more bearable and eco-friendly, and reliable future. Green Analytical Chemistry is more favourable, which reduces environmentally hazardous emissions originating from chemicals and chemical reaction processes.
Author:
Dipali Deshmukh
Assistant Professor
NRI Institute of Pharmaceutical Sciences, Bhopal